Patients are assuming that lab protocols are being followed and vigorous microbiological contamination control is established. Possible explanations for the lack of beneficial effects on clinical outcomes could be the source (bone marrow), route, dosage, frequency of administration, and delivery (lack of a bioactive scaffold). Stem cell therapy can be used in COPD treatment by introducing adult stem cells which can differentiate various cells especially those that are healthy to. First, we don’t know that reinjecting stem cells into your bloodstream is appropriate hoping that they will repair/regenerate injured tissue that needs it and not cause any harmful growth. Few human studies have investigated MSC treatment for chronic obstructive pulmonary disease, demonstrating short-term safety but no convincing benefits on clinical outcomes. Essential questions about MSC engraftment, retention, and survival have not been sufficiently addressed in a systematic manner.
Moreover, the regrowth potential of differentiated tissues and organs differs between species.
It is difficult to draw definitive conclusions from the available animal studies, as different models, dosage protocols, administration routes, and sources of MSCs have been used with different measures of effectiveness. Still, there are considerable challenges before effective stem cell treatment can be realized in emphysema patients. The optimism regarding this treatment strategy is supported by promising results from animal models. This review discusses the current state of the art regarding the potential of MSCs for the treatment of emphysema. MSCs do not only self-renew and differentiate into renew tissues, but also have anti-inflammatory and paracrine properties to reduce damage and to support tissue regeneration, constituting a promising cell-based treatment strategy for the repair of damaged alveolar tissue in emphysema. Mesenchymal stem or stromal cells (MSCs) are multipotent cells that play a pivotal role in various phases of lung development and lung homeostasis, and potentially also lung regeneration. Detailed Description: Through the collection of outcomes data, Lung Institute aims to explore and describe the safety and efficacy of autologous stem cell treatment for chronic lung disease with dissemination to the public and to the medical community for the advancement of regenerative medicine.
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